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EnjoyNT—a new food supplement for the health of joints—has been recently launched to the market, and the results are only starting to show. However, there are plenty of examples of the effect of glucosamine, a key ingredient of the EnjoyNT food supplement. For the past years more than 100 official studies of this substance have been held. We have selected the most remarkable and notable ones. 

Venice, Italy 

stat enjoy uchen2One of the first studies of the properties of glucosamine was conducted by Italian scientists back in 1980. They have surveyed 30 seniors (aged over 70), hospitalized with most severe forms of chronic osteoarthritis. During three weeks, half of the participants have been administered glucosamine sulfate in the form of injections and pills, whereas the second half of the patients—the control group—was treated with standard pain-relieving medicines, also in injections and pills. Both groups saw a significant improvement in the course of the disease and better functioning of joints. However, after the treatment period, a further significant improvement was recorded in the group that had received glucosamine, whereas the control group showed no such result. Eventually, four patients who underwent a course of glucosamine treatment were found to have no symptoms of osteoarthritis. No such cases of recovery were registered in the other group. 

Manila, Philippines 

Another survey was conducted under the supervision of Doctor Jose Pujalte and his colleagues from the National Orthopedic Hospital. The efficacy of a daily dose of 1500 mg of glucosamine sulfate was tested against placebo—sugary pills—in a clinical trial with 20 participants. Apart from this difference, all patients were provided with standard medical assistance. After 8 weeks patients from the first group experienced a significant alleviation of joint pains and reduction of tissue swelling with simultaneous improvement of joint flexibility. In the end of the study Doctor Pujalte noted that glucosamine not only beneficially influenced joints, but could also increase the efficacy of currently used methods of joint treatment. 

Laboratories in Pavia and Rotta, Italy 

Half of the patients hospitalized with acute osteoarthritis were given 1500 mg of glucosamine sulfate daily. As a result, after three weeks the state of 72% of the patients who received glucosamine, unlike the others, was classified as “good” or “excellent”. About 20% didn’t experience pains or other unpleasant symptoms of the disease any further. 

Along with that doctors took tissue samples from the femoral and knee cartilages from both groups for the purposes of a detailed study. The difference was stunning: cartilages of those who didn’t take glucosamine-containing pills had cavities, characteristic of heavy forms of osteoarthritis. Simultaneously, the other group of patients that did take glucosamine had smoother cartilage surface with low-grade osteoarthritis symptoms. According to the survey, regeneration of the cartilages took about 30 days. 

Doctor Drovanti and his colleagues conducted another experiment. Eighty patients aged around 60 have been taken to Vigevano Hospital for a month. All of them were diagnosed with arthritis of cervical and lumbar spine and joint arthritis, and were ensured absolute rest and physiotherapy treatment without any medicines. The procedure was uniform: half of the patients took 1500 mg of glucosamine sulfate daily, the other half—sugary placebo. Again, in the same way as before, significant improvement was observed in the first group. Torturous symptoms of the disease completely disappeared in ten cases out of forty. However, the second group showed no such picture of improvement. 

Obninsk, Russia 

stat enjoy uchenGlucosamine effectiveness for the treatment of joint diseases has been studied and clinically proved in outpatient settings at the Obninsk Radiological Scientific Centre of the Russian Academy of Medical Sciences in 1999. Here are but some extracts from the resulting medical report: 

“…We studied 63 patients, aged 40 to 70, 25 women and 38 men. 59 patients were diagnosed with polyosteoarthrosis and 3 of them—with rheumatoid arthritis. The diagnosis was established based on the clinical appraisal of the statistical data, medical examination, blood tests, biochemical and immunological tests, bone and joint radiography with colour decryption of radiograms, and radionuclide skeletal imaging. …Patients took 2 capsules of glucosamine twice a day for 30 days, half an hour before meals. No occurrence of intolerance to the administered drug was noted, no altering or discontinuing of the treatment was required…” 

As a result of the survey, the following conclusions were made:

  1. Glucosamine as a treatment of polyosteoarthrosis significantly improves the condition of patients.
  2. As a result, pains in knees and joints are significantly reduced or disappear, both at rest and in motion. According to the visual-analogue scale data, rates that characterize the level of pains drop as well as the palpatory sensitivity.
  3. Judging by skeletal imaging data, regeneration of the osteohondrous structures takes place in most patients due to the improvement of mineral metabolism.
  4. X-ray imaging shows that bone tissue density is restored due to the mineral metabolism normalization.
  5. Intake of glucosamine by the patients suffering from osteoarthrosis doesn’t involve significant changes of the biochemical blood picture and immunity reactions—apart from those that signify the alleviation of inflammatory processes in cartilaginous and connective tissue.
  6. No particular side effects have been observed during the treatment of the osteoarthrotic patients.
  7. This medicine has to be widely used for regular therapy of patients with the diseases of the musculoskeletal system.

Frankfurt, Germany 

Doctor Böhme and his colleagues have tested glucosamine sulfate supplements with 68 sportsmen who suffered from severe forms of the so-called “jumper’s knee” disease. Participants took 1500 mg of glucosamine sulfate daily for 40 days, and 0.75 mg—within further 90-100 days. Four weeks later knee pain ceased considerably. And after 8 weeks it was completely gone. 4-5 months later the sportsmen could start the same intensive training as before the trauma without any further complications or exacerbation. Medical examination that followed a year later confirmed an overall success of the therapy. 

New York, USA 

stat enjoy uchen1Researchers from the University of Columbia, New York, have discovered that glucosamine, regularly applied on surgical wounds, quickens their healing by 10%. These figures are seemingly insignificant, but bear in mind, however, that there are very few other remedies to accelerate the regenerative process. 

Chitine also accelerated the healing of surgical wounds by some 30% (chitine forms the basis of the exoskeleton of crabs, lobsters and insects). Chitine is a polymer substance that contains glucosamine. Researchers believe that after chitine is introduced into the healing tissue, ferments that participate in the healing process gradually start releasing glucosamine from chitine into the wound. 
Data from these experiments comply with the experimental results of adding glucosamine into cartilaginous tissue cultures. In other words, if healing tissues are provided with sufficient amounts of glucosamine, the regenerative process can significantly speed up. 

Oporto, Portugal 

Doctor Antonio Lopes Vaz has carried out a study involving 40 participants in order to compare the effectiveness of traditional ibuprofen-based and glucosamine-based medicines for osteoarthritis symptoms. 

The following results were published: within the first 2 weeks ibuprofen demonstrated a fast pain-relieving effect. However, 8 weeks later pain scores of patients who took glucosamine on average reduced by 3 times. 20% of those who took glucosamine saw the swelling of the knees disappear, unlike the patients of the other group.